Polypeptide (OATP)-enhanced multi-modality imaging

Student Researcher: Nivin Nyström, PhD Student, Western University Project Title: Improving the monitoring of triple-negative breast cancer metastasis in preclinical models with organic anion-transporting polypeptide (OATP)-enhanced multi-modality imaging Approximately 20%…

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PET/MRI to detect treatment response

Student Researcher: Matthew Mouawad, PhD Student, Western University Project Title: Investigating the utility of PET/MRI to detect treatment response to stereotactic body radiation therapy for early stage breast cancer The…

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Role of tumour associated macrophages

Student Researcher: Ashley Makela, PhD Student, Western University Project Title: Role of tumour associated macrophages (TAMs) in breast cancer progression The presence of cells called tumour-associated macrophages (TAMs) correlates strongly…

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Development of peptide-based drugs

Student Researcher: Alexandra Hauser-Kawaguchi, PhD student, Western University Project Title: Development of peptide-based drugs for the specific inhibition of RHAMM-HA interactions Receptor for hyaluronan mediated motility (RHAMM) is one of…

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Assessing acute cardiac inflammation

Student Researcher: Oi Wai (April) Choi, MSc student, Western University Project Title: Assessing acute cardiac inflammation after left-sided breast cancer radiotherapy with hybrid PET/MRI Radiation therapy (RT) of the breast…

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Radiotherapy-induced fibrosis

Investigation and treatment of radiotherapy-induced fibrosis in breast cancer Dr. Eva Turley, Senior Oncology Scientist, London Regional Cancer Program Breast cancer patients increasingly receive radiotherapy as a post-surgery (or adjuvant)…

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Targeting lung-derived proteins

This research team aims to understand the interactions between CD44+ breast cancer cells and CD44-interacting proteins produced by the lung microenvironment in order to determine how this helps migration and growth in the lung as part of the metastatic process. We are investigating whether we can use an inhaled drug delivery approach to directly inhibit CD44-interacting proteins in the lung as an effective strategy for reducing breast cancer metastasis as well as toxic side effects. By gaining a greater understanding of the underlying biology and therapeutic potential of lung-derived factors in breast cancer metastasis, we have the potential to positively impact breast cancer patient survival in the future.

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